The QRS narrowing index for easy and early identification of responder to cardiac resynchronization therapy

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OCUS ISSUE: CARDIAC RESYNCHRONIZATION THERAPY Normal QRS Duration and Resynchronization

Cardiac resynchronization therapy has been shown to be an effective treatment for patients with systolic ventricular dysfunction, prolonged ( 120 ms) QRS duration, and New York Heart Association (NYHA) functional class III or IV symptoms despite optimal medical therapy. However, studies show that a majority of heart failure patients have QRS duration 120 ms. We have been investigating the poten...

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Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration.

OBJECTIVES The goal of this study was to examine the relative impact of QRS morphology and duration in echocardiographic responses to cardiac resynchronization therapy (CRT) and clinical outcomes. BACKGROUND At least one-third of all patients treated with CRT fail to derive benefit. Patients without left bundle branch block (LBBB) or patients with smaller QRS duration (QRSd) respond less or n...

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QRS duration versus morphology and survival after cardiac resynchronization therapy

AIMS The prognostic implications of QRS duration and morphology in heart failure patients treated with cardiac resynchronization therapy (CRT) remains debated. The present evaluation investigated the association between QRS duration (<150 vs. ≥150 ms) and QRS morphology (left bundle brand block [LBBB] vs. non-LBBB) and long-term prognosis of a large cohort of unselected heart failure patients t...

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Cardiac resynchronization therapy in patients with a narrow QRS.

Although cardiac resynchronization therapy (CRT) is indicated in patients with moderate to severe heart failure with a wide QRS complex (> 120 ms), current guidelines exclude many heart failure patients with a narrow QRS. Detecting mechanical dyssynchrony on echocardiography has become a promising tool in selecting patients with a narrow QRS who may respond to CRT. Several small single-center s...

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Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT).

BACKGROUND This study aimed to determine whether QRS morphology identifies patients who benefit from cardiac resynchronization therapy with a defibrillator (CRT-D) and whether it influences the risk of primary and secondary end points in patients enrolled in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT) trial. METHODS AND RESULTS Base...

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ژورنال

عنوان ژورنال: International Journal of Cardiology

سال: 2014

ISSN: 0167-5273

DOI: 10.1016/j.ijcard.2013.11.057